I would like to offer you the cosy appartment direct in the city center at I. P. Pavlova. Subway is 50 meters from the building. 15 meters tram station. The location offers to you so many restaurants, pubs, clubs for party's and also nice places for the culture.
You will reach the Wencel's square in five minutes walk. You can visit nice parks Riegrovy sady or Folimanka in a few minutes.
I am living here more then nine years, I can give you many tips how can you enjoy Prague.